Grey's Anatomy: Who Plays Who? (1)

[D] Preston Burke | Cardiothoracic genius whose tremor storyline with Cristina created unforgettable surgical tension and romance.

[D] Callie Torres | Ortho badass whose parking lot musical number after the crash became instant classic.

[B] Adele Webber | Chief's wife whose Alzheimer's storyline and "My Funny Valentine" death destroyed hearts everywhere.

[C] Mark Sloan | McSteamy's bathroom entrance made jaws drop before becoming beloved plastics chief and father.

[D] Izzie Stevens | Model turned surgeon who cut LVAD wire for love and saw ghost sex storylines.

[B] Alex Karev | Evil Spawn transformed from jerk to pediatric surgeon before controversial Dear Jo exit.

[A] Meredith Grey | Dark and twisty narrator whose voiceovers became the show's emotional compass through every season.

[A] Miranda Bailey | Nazi nickname hid mama bear heart, earning her journey from resident to Chief position.

[C] Lexie Grey | Photographic memory Little Grey died confessing love during the plane crash's devastating finale.

[B] Richard Webber | Chief's alcoholism battle and Ellis Grey affair shaped decades of Seattle Grace history.

[C] Derek Shepherd | McDreamy's elevator proposal and Post-It wedding became legendary moments before his heartbreaking death.

[A] Cristina Yang | Dancing queen surgical robot whose "my person" friendship defined the show's emotional core.

[A] Owen Hunt | Army trauma surgeon brought PTSD awareness while choking Cristina during nightmares shocked viewers.

[A] Rebecca Pope | Ava/Rebecca's fake pregnancy and identity crisis pushed Alex's character development forward significantly.

[B] Addison Montgomery | Satan herself arrived wearing Prada, then earned her spinoff Private Practice after winning hearts.

[D] Denny Duquette | Heart patient whose LVAD wire death haunted Izzie through ghost appearances and millions.

[C] George O'Malley | 007 license to kill evolved into heroic army medic dying saving bus passengers.